On November 19, 2018 the prime and backup crews of crew transportation spacecraft Soyuz MS-11 arrived at the Baikonur launch site to go through the final stages of prelaunch preparations.

The prime crew of ISS-58/59 consists of Roscosmos cosmonaut Oleg Kononenko, CSS astronaut David Saint-Jacques and NASA astronaut Anne McClain. Their backups are Rosocosmos cosmonaut Alexander Skvortsov, ESA astronaut Luca Parmitano and NASA astronaut Andrew Morgan.